Pulmonary metastasis of giant cell tumor of bones
نویسندگان
چکیده
Giant cell tumor of bone (GCTB) accounts for 5% of primary skeletal tumors. Although it is considered to be a benign lesion, there are still incidences of pulmonary metastasis. Pulmonary metastasis of GCTB may be affected by tumor grading and localization as well as the age, gender and overall health status of the patient. Patients with local recurrence are more likely to develop pulmonary metastasis of GCTB. High expression of some genes, cytokines and chemokines may also be closely related to the metastatic potential and prognosis of GCTB. The treatment of the primary GCTB is key to the final outcome of the disease, as intralesional curettage has a significantly higher local recurrence and pulmonary metastasis rate than wide resection. However, even patients with pulmonary metastasis seem to have a good prognosis after timely and appropriate surgical resection. It is hoped that with the development of novel surgical methods and drugs, pulmonary metastasis of GCTB can be prevented and treated more effectively.
منابع مشابه
Giant cell tumor of maxillary sinus: A case report
Giant cell tumor (GCT) is a benign primary bone neoplasm that usually occurre in the long bones. The skull is affected in only 1% of cases, predominantly in the sphenoid and temporal bones. Maxillary sinus involvement is exceedingly rare. The case is a 26 year-old man presented with history of gradually increasing swelling in the right side of face without any history of trauma or systemic diso...
متن کاملA very rare case of metachronous multicentric giant cell tumor of bone with benign lung metastasis in form of a very large mass lesion
Giant cell tumour (GCT) is a benign, locally aggressive tumour of the bone that accounts for 5% of primary bone tumours and 21% of benign bone tumours. This tumour more commonly presents as a single (solitary) lesion; however, it may appear with multiple (multicentric) lesions in less than 1% of the cases. According to the literature, 1-9% of solitary GCTs metastasizes to the lung, more commonl...
متن کاملThe Epidemiologic Characteristics, Clinical Behavior and Outcome of the Giant Cell Tumor of Bone: a Retrospective Single-Center Study
Abstract Objects:Giant cell tumor of bone (GCTB) isa locally aggressive lesion with unpredictable behavior. Here, we aim to evaluate the epidemiological characteristics, clinical and functional outcome of GCTB in a relatively large series of patients. Methods:Patients with the diagnosis of GCTB were included in this retrospective study.Surgical options included extended curettage wh...
متن کاملGiant cell tumor of patella: A case report and review of literature
Objective: Patella is a sesamoid bone which develops in the quadriceps tendon. It is an uncommon site for neoplasms. The most common primary tumors which involve patella are benign. These include chondroblastoma, giant cell tumor (GCT) and aneurysmal bone cyst. Malignant lesions are less common in patella. These encompass metastasis, osteosarcoma and hemangioendothelioma. The most common compla...
متن کاملThe Most Appropriate Reconstruction Method Following Giant Cell Tumor Curettage: A Biomechanical Approach
Giant cell tumor (GCT) is a primary and benign tumor of bone, albeit locally aggressive in some cases, such as in the epi-metaphyseal region of long bones, predominantly the distal end of femur and proximal end of tibia (1). There are a variety of treatments for a bone affected by GCT, ranging from chemotherapy, radiotherapy, embolization, and cryosurgery, to surgery with the use of chemical or...
متن کامل